Journal of Molecular Cell Biology

Letters to the Editor

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Modeling of COVID-19 disease disparity in gastric organoids reveals the spatiotemporal dynamics of SARS-CoV-2 infectivity

Wenwen Wang^1,2,† , Fengrui Yang^1,2,3,† , Jie Lin^4,† , Saravanakumar Muthusamy^2,† , Shihao Du^1,4 , McKay Mullen^1,2 , Fatima Garba² , Wanjuan Wang^1,4 , Xu Liu^1,2,3 , Tao Li^1,4 , Zhihong Yang³ , Xia Ding⁴ , Felix Aikhionbare² , Xinjiao Gao¹ , Zhikai Wang^1,2,* , Xing Liu^1,2,* , Xuebiao Yao^1,*

¹MOE Key Laboratory for Cellular Dynamics, University of Science & Technology of China School of Life Sciences, Hefei 230027, China
²Keck Center for Organoids Plasticity and Department of Surgery, Morehouse School of Medicine, Atlanta, GA 30310, USA
³Anhui Key Laboratory for Cellular Dynamics & Chemical Biology, CAS Center of Excellence in Molecular Cell Sciences, Hefei 230027, China
⁴Department of Gastroenterology, Beĳing University of Chinese Medicine, Beĳing 100081, China
^†These authors contributed equally to this work.
^*Correspondence to:Zhikai Wang , Email:wangzk@mail.ustc.edu.cn Xing Liu , Email:xing1017@ustc.edu.cn Xuebiao Yao , Email:yaoxb@ustc.edu.cn

J Mol Cell Biol, Volume 14, Issue 2, February 2022, mjac007, https://doi.org/10.1093/jmcb/mjac007

Dear Editor,

The promptness and continuous expansion of the coronavirus disease 2019 (COVID-19) pandemic, elicited by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its variants, has presented an unprecedented impact on human health (WHO Coronavirus (COVID-19) Dashboard, 2021). Although vaccination has attenuated the severe symptoms, there is no specific antiviral medication available for preventing the viral spread (Drayman et al., 2021). A well-documented COVID-19 case study exhibited the temporal dynamics of disease progression and related symptoms (Holshue et al., 2020), and gastrointestinal epithelial cells are susceptible to SARS-CoV-2 infection (Han et al., 2021).

Volume 14, Issue 2
February 2022

Letters to the Editor

< Previous

Modeling of COVID-19 disease disparity in gastric organoids reveals the spatiotemporal dynamics of SARS-CoV-2 infectivity

Wenwen Wang1,2,† , Fengrui Yang1,2,3,† , Jie Lin4,† , Saravanakumar Muthusamy2,† , Shihao Du1,4 , McKay Mullen1,2 , Fatima Garba2 , Wanjuan Wang1,4 , Xu Liu1,2,3 , Tao Li1,4 , Zhihong Yang3 , Xia Ding4 , Felix Aikhionbare2 , Xinjiao Gao1 , Zhikai Wang1,2,* , Xing Liu1,2,* , Xuebiao Yao1,*

J Mol Cell Biol, Volume 14, Issue 2, February 2022, mjac007, https://doi.org/10.1093/jmcb/mjac007